Syndrome of aspirin-exacerbated respiratory disease (AERD)

According to the study of Prostaglandins and leukotrienes as inflammatory mediators by John A Salmon and Gerald A Higgs(a), Leukotrienes is produced in leukocytes as a result of oxidative metabolism of arachidonic acid by the enzyme arachidonate 5-lipoxygenase, belonging to the family of eicosanoid inflammatory mediators(a). Its production is usually accompanied by the production of histamine and prostaglandins.
Syndrome of aspirin-exacerbated respiratory disease (AERD)
Chronic rhinosinusitis (CRS) with nasal polyposis (NP) may be associated with hypersensitivity to nonsteroidal anti-inflammatory drugs, representing a syndrome of aspirin-exacerbated respiratory disease (AERD). According to the study by the Jagiellonian University Medical College, among CRS subjects requiring functional endoscopic sinus surgery (FESS), as many as 33.3% may have AERD and respond to a small provocative dose of aspirin with bronchoconstriction and/or mucosal and skin edema. A simple and inexpensive measurement of uLTE4 (leukotriene E4) can help diagnose AERD in patients with CRS with sensitivity of 87.5%, but its specificity is limited and depends on the arbitrary threshold of uLTE4(25).
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity

Back to home of living health of 50 and over http://healthyliving50over.blogspot.ca/

Back to Hormones http://medicaladvisorjournals.blogspot.ca/p/hormones.html

 

Sources

(a) http://bmb.oxfordjournals.org/content/43/2/285   
(25) http://www.ncbi.nlm.nih.gov/pubmed/22814420